Science News-Dasatinib Excels in Worldwide Phase II Trial Against Pediatric CML

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Medical News Dasatinib Excels in Worldwide Phase II Trial Against Pediatric CML Worldwide phase II clinical trial results presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2017 show the promise of the second-generation drug dasatinib against pediatric CML. Of 113 pediatric patients studied, 75 percent... – University of Colorado Cancer Center ASCO 2017 Embargo expired on 05-Jun-2017 at 08:00 ET CONNECT Registry Shows Only 9 Percent Compliance with Genetic Testing Guidelines for Aml Study presented at ASCO 2017 shows that only 9 percent of 259 evaluated AML patients received all seven of the NCCN-recommended genetic tests. – University of Colorado Cancer Center ASCO 2017 Embargo expired on 05-Jun-2017 at 08:00 ET Penn Effort to Expand Trials of Olaparib Leads to New Treatment Options for Patients with Advanced BRCA-Related Breast Cancer Six years ago an international team of physician scientists known as BRCA-TAC led a charge to advance clinical testing of the PARP inhibitor olaparib in cancer patients with known inherited mutations in BRCA1 and BRCA2. This weekend during the plenar... – Perelman School of Medicine at the University of Pennsylvania 2017 ASCO Annual Meeting Embargo expired on 04-Jun-2017 at 06:30 ET Real-Time, Patient-Reported Symptom Monitoring Demonstrates an Overall Survival Benefit Updated results of a clinical trial that launched in 2007 were presented today by Ethan Basch, MD, of Memorial Sloan Kettering Cancer Center (MSK) and UNC Lineberger Comprehensive Cancer Center, at the annual meeting of the American Society of Clinic... – Memorial Sloan Kettering Cancer Center ABSTRACT #LBA2 Embargo expired on 04-Jun-2017 at 07:30 ET Phase III Trial of PARP Inhibitor Shows First Evidence of Improved Outcomes in Breast Cancer The first phase III trial of a PARP inhibitor used to treat breast cancer reported promising data at the annual meeting of the American Society of Clinical Oncology (ASCO). Mark Robson, MD, Clinic Director of the Clinical Genetics Service and medical... – Memorial Sloan Kettering Cancer Center #LBA4 Embargo expired on 04-Jun-2017 at 07:30 ET Two Combination Therapies Shrink Melanoma Brain Metastases in More Than Half of Patients A combination regimen of two immunotherapies and another of two targeted therapies each significantly shrank metastatic brain tumors in at least 50 percent of patients in separate multi-center clinical trials presented today at the 2017 ASCO Annual M... – University of Texas M. D. Anderson Cancer Center 2017 ASCO Annual Meeting Embargo expired on 04-Jun-2017 at 10:00 ET Enhanced Test for Urinary Tract Infections Detects More Bacteria Than Standard Test One of the primary ways physicians diagnose urinary tract infections is with a test that detects bacteria in urine. A new enhanced test detects significantly more bacteria than the standard test, according to a study presented at a meeting of the Ame... – Loyola University Health System American Society for Microbiology Embargo expired on 03-Jun-2017 at 14:15 ET Immunotherapy Drug Effective for Metastatic Triple Negative Breast Cancer Immunotherapy trial in metastatic triple negative breast cancer patients proves to shrink tumors in patients. – NYU Langone Medical Center ASCO Annual Meeting Jun-2017 Embargo expired on 03-Jun-2017 at 16:50 ET Results Indicate That Larotrectinib Is Effective as the First Novel Targeted Therapy to Show a Consistent Response across Multiple Tumor Types in Adult and Pediatric Patients Larotrectinib (LOXO-101) has demonstrated consistent and durable antitumor activity in tropomyosin receptor kinase (TRK) fusion cancers across a wide range of patient ages and tumor types and was well tolerated by patients, according to results from ... – Memorial Sloan Kettering Cancer Center ASCO meeting #LBA2501 Embargo expired on 03-Jun-2017 at 07:30 ET Novel Sequencing Approach Seeks to Detect Cancer’s Genomic Alterations Findings from an early study evaluating a sophisticated new genomic-sequencing approach that analyzes cell-free DNA (cfDNA) in the blood of people with advanced cancer will help inform development of a future assay that could potentially detect cance... – Memorial Sloan Kettering Cancer Center ASCO Annual Meeting LBA11516 Embargo expired on 03-Jun-2017 at 07:30 ET Lawn Mower Injuries Send 13 Children to the Emergency Department Every Day A recent study from the Center for Injury Research and Policy at Nationwide Children’s Hospital published in the American Journal of Emergency Medicine shows that, while there has been a decrease in the number of children injured by lawn mowers ove... – Nationwide Children's Hospital Simple Step to Protect People with Type 1 Diabetes Against Heart Disease One additional injection of insulin three hours after eating has been shown to protect people with type 1 diabetes from cardiovascular disease – the leading cause of death among people with the condition – Leeds Beckett University Diabetes and Vascular Disease Research New Transplant Technology Could Benefit Patients with Type 1 Diabetes Combining a new hydrogel material with a protein that boosts blood vessel growth could improve the success rate for transplanting insulin-producing islet cells into persons with type 1 diabetes. – Georgia Institute of Technology Science Advances; 2-SRA-2014-287-Q-R; T90-DK097787-03; F30AR069472 includes video Genetic Sequencing Could Influence Treatment for Nearly Three-Quarters of Advanced Cancer Patients A new analysis finds that nearly three-quarters of 500 patients with advanced cancer could be referred to a potential targeted treatment based on the results of a comprehensive analysis of their tumor’s genetic landscape. – Michigan Medicine - University of Michigan American Society of Clinical Oncology Annual Meeting June 2017; 1UM1HG006508; CA214170; CA186786 STD Treatment for Two? In some states, patients who test positive for chlamydia or gonorrhea leave the clinic with not only a prescription for themselves, but also one for their sexual partner — who was not seen by a doctor. – Michigan Medicine - University of Michigan Immunotherapy Combination Shows Promise in Early Stage Triple Negative Breast Cancer Immune checkpoint inhibitor (durvalumab/MEDI4736) with chemotherapy as a preoperative treatment shows promise in early stage TNBC. – Yale Cancer Center Timing Meals Later at Night Can Cause Weight Gain and Impair Fat Metabolism New findings suggest eating late at night could be more dangerous than you think. Compared to eating earlier in the day, prolonged delayed eating can increase weight, insulin and cholesterol levels, and negatively affect fat metabolism, and hormonal ... – Perelman School of Medicine at the University of Pennsylvania SLEEP2017; R21 DK100787 Are Soft Contact Lenses Safe for Children? Risks Seem No Higher Than in Adults Available evidence suggests that soft contact lenses can be safely prescribed to children and adolescents, with no increase in adverse effects compared to adults, according to a review in the June issue of Optometry and Vision Science, the official j... – Wolters Kluwer Health: Lippincott Williams and Wilkins Optometry and Vision Science Low-Dose THC Can Relieve Stress; More Does Just the Opposite Researchers at the University of Illinois at Chicago and the University of Chicago report that low levels tetrahydrocannabinol, or THC, the main psychoactive compound in marijuana, does reduce stress, but in a highly dose-dependent manner: – University of Illinois at Chicago Drug & Alcohol Dependence One in Three Hospitalized Patients Experience Symptoms of Depression, Study Shows About one in three hospitalized patients shows symptoms of depression, potentially affecting their clinical outcomes, a new Cedars-Sinai study has found. The study appears in the Journal of Hospital Medicine and shows that screening hospitalized pati... – Cedars-Sinai Journal of Hospital Medicine Combination Therapy Targets Genetic Mutation Found in Many Cancers A study at The University of Texas MD Anderson Cancer Center has shown promise for effective treatment of therapy-resistant cancers caused by a mutation of the RAS gene found in many cancers. The pre-clinical study combined therapies targeting the in... – University of Texas M. D. Anderson Cancer Center Chemical “Dance” of Cobalt Catalysis Could Pave Way to Solar Fuels In a new study, scientists at the U.S. Department of Energy’s (DOE) Argonne National Laboratory and Harvard University have been able to see for the first time an especially important chemical step in the process of splitting water into hydrogen an... – Argonne National Laboratory Proceedings of the National Academy of Sciences, Mar-2017 UC San Diego Media Advisory The University of California San Diego, one of the top 15 research universities in the world and recognized for its contributions to the public good, will host His Holiness the 14th Dalai Lama for a June 16 public address and June 17 keynote commence... – University of California San Diego Website Provides Mental and Behavioral Health Resources for Teens TLC4Teens.org offers a vetted directory of educational websites and hotlines for children and their parents – Rutgers University Treating Depression with Software: Technology From Mount Sinai Steps Into the Digital Healthcare Universe A treatment for depression using Emotional Faces Memory Task (EFMT), a technology originally developed by two Mount Sinai researchers, resulted in a significantly greater reduction of major depressive disorder (MDD) symptoms compared to a control gro... – Mount Sinai Health System D-Day Invasion Was Bolstered by UW–Madison Penicillin Project Seventy-three years ago Tuesday, on June 6, 1944, the D-Day invasion of Normandy was bolstered by millions of doses of a precious new substance: penicillin. On the other side of the Atlantic, researchers at the University of Wisconsin–Madison and o... – University of Wisconsin-Madison ISPOR 22nd Annual International Meeting Drew Key Stakeholders and Thought Leaders to Discuss Social and Policy Changes in Health Care ISPOR recently concluded its 22nd Annual International Meeting in Boston, MA, USA. The conference attracted 4,195 delegates representing 76 countries—the largest attendance to date for the Society’s Annual International Meeting. – International Society for Pharmacoeconomics and Outcomes Research (ISPOR) ISPOR Annual International Meeting, May-2017 Men: Start Your Path to a Healthier You with 7 Tips Physicians at UAB share tips on men’s health and how it affects heart health, sexual function and memory and decreases cancer risk. – University of Alabama at Birmingham Robert Terry, Co-Founder of U.S. Alzheimer’s Research Dies at 93 A founder of U.S. Alzheimer’s research, Robert D. Terry, has died at 93. He first showed what plaques and tangles look like in the electron microscope, and linked failing cognition to withering synapses in the brain. – Alzforum Dr. Reza Dana to Receive Friedenwald Award From the Association for Research in Vision and Ophthalmology The Association for Research in Vision and Ophthalmology (ARVO) recently announced that Reza Dana, M.D, MPH, M.Sc., Director of Cornea and Refractive Surgery at Massachusetts Eye and Ear and a resident of Newton, Mass., will receive the prestigious F... – Massachusetts Eye and Ear Four Dana-Farber Researchers Awarded Prestigious “Outstanding Investigator Awards” by National Cancer Institute The National Cancer Institute (NCI) has awarded four Dana-Farber Cancer Institute researchers with Outstanding Investigator Awards (OIA) for ongoing progressive research within their respective areas of study. – Dana-Farber Cancer Institute Penn’s David Dinges Honored with Distinguished Service Award David F. Dinges, PhD, chief of the division of Sleep and Chronobiology, and director of the Unit for Experimental Psychiatry in the Perelman School of Medicine at the University of Pennsylvania, has received the Nathaniel Kleitman Distinguished Servi... – Perelman School of Medicine at the University of Pennsylvania Researchers Receive $7.7 Million Grant to Study West Nile and Zika Viruses A Georgia State University researcher, in collaboration with researchers at the University of Pennsylvania and Florida State University, has received a five-year, $7.7 million federal grant to study the consequences of West Nile and Zika virus infect... – Georgia State University Facial Nerve Clinic to Provide Comprehensive Personalized Care A multidisciplinary team will provide patients with advanced technology to diagnose and manage facial nerve disorders. – University of Alabama at Birmingham Science News UF Scientists Find Way to Surgically Strike Out Weeds That Impede Crop Growth Researchers say this will help growers as they try to manage pests in areas where they cause the most trouble. – University of Florida Institute of Food and Agricultural Sciences Story Tips From the Department of Energy's Oak Ridge National Laboratory, June 2017 Economical approach created to locate oil- and natural gas-rich shale; electrochemical and ferroelectric link in ultrathin crystalline films discovered; Dallas-based company non-exclusively licensed 3D-printed magnets of recycled materials; Simple sy... – Oak Ridge National Laboratory Catching the IMSI-Catchers: SeaGlass Brings Transparency to Cell Phone Surveillance University of Washington security researchers have developed a new system called SeaGlass to detect anomalies in the cellular landscape that can indicate where and when IMSI-catchers, cell site simulators, Stingrays and other cell phone surveillance ... – University of Washington Proceedings on Privacy Enhancing Technologies Scientists Launch Global Agenda to Curb Social and Human Rights Abuses in the Seafood Sector As the United Nations Oceans Conference convenes in New York, a new paper calls on marine scientists to focus on social issues such as human rights violations in the seafood industry. – University of Washington Science, June-2017 Major Ivory Trafficker Jailed in Republic of Congo Northern Congo’s notorious elephant poacher and ivory trafficker Daring Dissaka, 39, has been convicted and sentenced to five years imprisonment. – Wildlife Conservation Society includes video UW, UW Bothell Scientists Explain New Discovery in Gravitational Wave Astronomy The announcement that a third collision of black holes has been detected three billion light years away validates the work of hundreds of scientists, including teams at the University of Washington and UW Bothell. – University of Washington An X-Ray Laser’s New Corrective “Eyeglasses” A new type of lens improves the focusing precision at the world’s most powerful X-ray light sources. – Department of Energy, Office of Science Nature Communications 8, 14623 (2017). [DOI: 10.1038/ncomms14623] Understanding Tungsten “Fuzz” New work seeks to explain a strange phenomenon occurring in fusion reactor materials. – Department of Energy, Office of Science Scientific Reports 7, 42315 (2017). [DOI: 10.1038/srep42315]; Acta Materialia 124, 556-567 (2017). [DOI: 10.1016/j.actamat.2016.11.042]; Scripta Materialia 127, 132-135 (2017). [DOI: 10.1016/j.scriptamat.2016.09.018]... New Book by UK Faculty Member Guides STEM Students in Career Planning A new book co-written by Nathan Vanderford, University of Kentucky assistant professor in the Department of Toxicology and Cancer Biology, guides STEM graduate and postdoctoral students in their career planning by evaluating goals and finding the ste... – University of Kentucky Missouri S&T Team Wins International Mars Rover Competition A team of students from Missouri University of Science and Technology has won the University Rover Challenge, an international design competition where teams showcase potential next-generation Mars rovers. – Missouri University of Science and Technology JSA Awards Graduate Fellowships for Research at Jefferson Lab Jefferson Sciences Associates announced today the award of eight JSA/Jefferson Lab graduate fellowships. The doctoral students will use the fellowships to support their advanced studies at their universities and conduct research at the Thomas Jeffers... – Thomas Jefferson National Accelerator Facility Developing Guidelines for Asphalt Bonding Agents The durability of an asphalt road depends on the bonding of the layers—that’s why research on tack coat selection and application will help make highways in the Midwest last longer. – South Dakota State University American Society for Biochemistry and Molecular Biology Selects New Leaders The American Society for Biochemistry and Molecular Biology announced this week the election and appointment of seven new society leaders. They begin their terms July 1. – American Society for Biochemistry and Molecular Biology (ASBMB) Lifestyle & Social Sciences Cell Phone Use and Distracted Driving Begins in the Mind Even simple cell phone conversations can cause distracted driving. Researchers have found listening on the phone while driving creates a lag in the mind to extract itself from one object before fixing attention on another object. Results appear in th... – University of Iowa Embargo expired on 05-Jun-2017 at 00:00 ET Class of 2017: How Darden Helped This Cameroon Native Find Her Voice Gaelle Mawadjou Tchokoua, who walked the Lawn as a member of the Class of 2017 last month, felt the impact of her experience at the University of Virginia’s Darden School of Business shortly after arriving on Grounds. – University of Virginia Darden School of Business Give It a Rest, Part 2: Productivity Lessons From Olympians and Google Professor Manel Baucells discusses his research that shows quantitatively how valuable breaks and rest are to productivity. – University of Virginia Darden School of Business HSU Signs Letter of Commitment to Paris Agreement Humboldt State University has signed on to a statement of support for the principles and targets of the Paris Agreement. The letter is from mayors, governors, university leaders, and businesses from across the country. – Humboldt State University New Training Aims to Improve Operational Security at U.S. Border DHS S&T, at USBP's request, developed training to assist in increasing tracking abilities. Tracking, or “sign cutting,” is identifying telltale indicators of movement through the southern border’s desert or northern border’s wooded areas. – Homeland Security's Science & Technology Directorate